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doi: 10.1016/j.ecl.2012.04.017 99 HottaMShibasakiTMasudaAImakiTSuginoNDemuraHet al

doi: 10.1001/jama.2015.5370

Throughout puberty and the post-pubertal period, girls with polycystic ovarian syndrome, a hallmark of adrenarche, experienced symptoms like PCOS, which were linked to acute stimulation of the gonadotropin-releasing hormone (GnRH)

Resistant cells generate more glutathione, elicit nuclear factor erythroid 2-related factor 2 (NRF2) activation, and overexpress many anti-oxidative genes such as superoxide dismutase, catalase, glutathione peroxidase, and thioredoxin reductase, providing stronger antioxidant capacity to survive in a more oxidative environment due to the sharp rise in oxidative metabolism and reactive oxygen species generation