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This is supported by studies showing that ascorbate release occurs before corticosteroid release in the adrenal gland after systemic administration of ACTH to hypophysectomized rats (105), a finding that suggests ascorbate must first be released by the adrenal gland for steroid synthesis (or release) to begin when there is stress

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They can disrupt the body's natural processes in many ways: mitochondrial function, stress hormone production, brain function, adrenal function, thyroid T4/T3 conversion, immune system regulation, virus susceptibility, reduced glutathione stores, increased inflammation, and reduced detoxification