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Clusterin-carrying extracellular vesicles derived from human umbilical cord mesenchymal stem cells restore the ovarian function of premature ovarian failure mice through activating the PI3K/AKT pathway

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At the receptor level, PEG-MGF is understood to activate IGF1R through its IGF-1-derived sequence while simultaneously engaging putative MGF-specific receptors or co-receptors that are proposed to mediate satellite cell activation independent of canonical IGF1R signalling

Initial Loading Phase Protocol In this first step, patients get B12 shots every day for one to two weeks