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Reflecting this evidence, clinical guidelines increasingly support GLP-1 receptor agonists as an appropriate first-line or add-on treatment option when obesity pharmacotherapy is indicated, in conjunction with comprehensive lifestyle interventions

For instance, studies in laboratory rodents have found that dietary omega-3 PUFA deficiency impaired measures of cognitive performance through influencing the dopamine neurotransmitter system in the frontal cortex region of the brain (98)

This process involves extensive animal testing followed by multiple phases of human clinical trials to establish both safety and efficacy